Blok P, Craanen M E, Dekker W, Offerhaus G J, Tytgat G N
Department of Gastroenterology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Histopathology. 1998 Apr;32(4):335-9. doi: 10.1046/j.1365-2559.1998.00376.x.
Conflicting data on c-erbB-2 overexpression in gastric carcinomas can be found in the literature with regard to overall prevalence, prognostic significance and the histological type according to Lauren. The majority of these studies have focused on advanced gastric carcinomas whereas data on c-erbB-2 overexpression in early gastric carcinomas, especially of Caucasian origin, are relatively sparse. We therefore examined a series of Caucasian early gastric carcinomas to assess overall c-erbB-2 overexpression and to correlate c-erbB-2 overexpression, if any, with the type of growth pattern and the Lauren type.
Forty-five paraffin-embedded gastrectomy specimens from early carcinomas were examined for the presence of chronic active gastritis, chronic atrophic gastritis, subtypes of intestinal metaplasia and dysplasia. The Lauren type and the type of growth pattern were reassessed for all early carcinomas. c-erbB-2 overexpression was assessed with monoclonal antibody 3B5 and polyclonal antibody A485. Complete absence of c-erbB-2 overexpression was observed in chronic active gastritis, chronic atrophic gastritis, subtypes of intestinal metaplasia, and dysplasia. Moreover, c-erbB-2 overexpression was found absent in both intestinal-type (n = 20) and diffuse-type early gastric carcinomas (n = 25), irrespective of growth type.
c-erbB-2 overexpression does not play a role in the progression from normal to neoplastic gastric mucosa and should be considered as a late event in gastric carcinogenesis. Moreover, c-erbB-2 overexpression does not discriminate between intestinal and diffuse type early gastric carcinomas of Caucasian origin. Finally, it appears that mechanisms other than c-erbB-2 overexpression underlie the reported differences in biological behaviour of early gastric carcinomas with different types of growth pattern.
关于胃癌中c-erbB-2过表达，在文献中可发现有关总体患病率、预后意义以及根据劳伦分类法的组织学类型的相互矛盾的数据。这些研究大多集中在进展期胃癌，而关于早期胃癌尤其是白种人来源的早期胃癌中c-erbB-2过表达的数据相对较少。因此，我们检查了一系列白种人早期胃癌，以评估c-erbB-2的总体过表达情况，并将c-erbB-2过表达（如果存在的话）与生长模式类型和劳伦类型相关联。
对45例早期癌石蜡包埋的胃切除标本检查是否存在慢性活动性胃炎、慢性萎缩性胃炎、肠化生亚型和发育异常。对所有早期癌重新评估劳伦类型和生长模式类型。用单克隆抗体3B5和多克隆抗体A485评估c-erbB-2过表达。在慢性活动性胃炎、慢性萎缩性胃炎、肠化生亚型和发育异常中均未观察到c-erbB-2过表达。此外，无论生长类型如何，在肠型（n = 20）和弥漫型早期胃癌（n = 25）中均未发现c-erbB-2过表达。
c-erbB-2过表达在胃黏膜从正常向肿瘤性转变过程中不起作用，应被视为胃癌发生过程中的晚期事件。此外，c-erbB-2过表达不能区分白种人来源的肠型和弥漫型早期胃癌。最后，似乎除了c-erbB-2过表达之外的其他机制是不同生长模式的早期胃癌生物学行为差异的基础。
