Goteri G, Ranaldi R, Pileri S A, Bearzi I
Institute of Pathological Anatomy and Histopathology, University of Ancona, Italy.
Histopathology. 1998 Apr;32(4):348-55. doi: 10.1046/j.1365-2559.1998.00409.x.
Five cases of primary gastrointestinal (GI) lymphoma (three in the stomach, one in the ileum (IPSID) and one in the colon) associated with localized AL amyloidosis were studied to identify morphological or immunohistochemical features which could explain the amyloid deposition.
All the cases were low-grade marginal zone B-cell lymphomas; one case of gastric lymphoma and the IPSID also had a high-grade component. The lymphomas had a monoclonal plasma cell population, with different light and heavy-chain type expression in the five cases. Plasma cell differentiation was closely associated with the amyloid deposits. The latter were an incidental microscopic finding in one case, but produced tumoral masses in the other.
The presence of amyloid in primary GI lymphoma is rare, but can have diagnostic value. In the present study, neither particular features of the lymphomatous proliferation nor specific agents are identified. Therefore, the factors predisposing to amyloid deposition require elucidation.
对5例与局限性AL淀粉样变性相关的原发性胃肠道（GI）淋巴瘤（3例发生于胃，1例发生于回肠（免疫增殖性小肠疾病），1例发生于结肠）进行研究，以确定能够解释淀粉样蛋白沉积的形态学或免疫组化特征。
所有病例均为低级别边缘区B细胞淋巴瘤；1例胃淋巴瘤和免疫增殖性小肠疾病还具有高级别成分。淋巴瘤具有单克隆浆细胞群体，5例病例中轻链和重链类型表达不同。浆细胞分化与淀粉样蛋白沉积密切相关。淀粉样蛋白沉积在1例病例中是偶然的显微镜下发现，但在其他病例中形成肿瘤性肿块。
原发性胃肠道淋巴瘤中淀粉样蛋白的存在罕见，但可能具有诊断价值。在本研究中，未发现淋巴瘤增殖的特定特征或特定因子。因此，需要阐明易导致淀粉样蛋白沉积的因素。
