Leonard N, Alcutt D A, Farrell M A
Department of Neuropathology, Beaumont Hospital, Dublin, Ireland.
Histopathology. 1998 Apr;32(4):375-8. doi: 10.1046/j.1365-2559.1998.00407.x.
To report the previously undescribed phenomenon of extensive meningeal gliomatosis in a pleomorphic xanthoastrocytoma (PXA) and to examine possible prognostic features.
An 11-year-old girl underwent excision of a left temporoparietal pleomorphic xanthoastrocytoma and 8 months later underwent re-excision of a local tumour recurrence. Although mitoses were not present in any of the resection specimens, the development of necrosis and increased immunoreactivity for proliferating cell nuclear antigen (PCNA) indicated anaplastic transformation in the recurrent tumour. Three months later extensive meningeal gliomatosis with minimal local recurrence resulted in death.
Subarachnoid dissemination of a locally recurrent PXA in the absence of mitotic activity is an extremely unusual occurrence. PCNA expression in the initial excision specimens did not predict subsequent anaplastic transformation.
报告多形性黄色星形细胞瘤（PXA）中广泛脑膜胶质瘤病这一此前未被描述的现象，并研究可能的预后特征。
一名11岁女孩接受了左颞顶叶多形性黄色星形细胞瘤切除术，8个月后因局部肿瘤复发再次接受切除。尽管在任何切除标本中均未发现有丝分裂，但坏死的出现以及增殖细胞核抗原（PCNA）免疫反应性增加表明复发性肿瘤发生了间变转化。3个月后，广泛的脑膜胶质瘤病伴最小程度的局部复发导致患者死亡。
在无有丝分裂活性的情况下，局部复发的PXA发生蛛网膜下腔播散是极其罕见的情况。初始切除标本中的PCNA表达并不能预测随后的间变转化。
