Andersson K, Wrammert J, Leanderson T
Department of Cellular and Molecular Biology, Lund University, Sweden.
Immunol Rev. 1998 Apr;162:173-82. doi: 10.1111/j.1600-065x.1998.tb01440.x.
Affinity selection of antibodies during immune responses relies on two mechanisms, one molecular that involves the targeted introduction of somatic mutations into rearranged immunoglobulin genes and one cellular that involves the clonal expansion of B cells expressing a surface immunoglobulin with a higher affinity for antigen compared to their competitors. In this review we focus on the conditions for affinity selection during the establishment, expansion and memory phases of the immune response. We postulate that somatic mutation evolved prior to affinity selection and we present a model for selection of B cells in germinal centres. We also discuss the possibility that antibody repertoire shift occurs during the memory maintenance phase. Finally, we argue that a significant affinity selection and a selection for polyclonality of immune responses occur during this stage of the immune response.
免疫反应过程中抗体的亲和力选择依赖于两种机制，一种是分子机制，涉及将体细胞突变靶向引入重排的免疫球蛋白基因；另一种是细胞机制，涉及表达对抗原亲和力高于其竞争者的表面免疫球蛋白的B细胞的克隆扩增。在本综述中，我们聚焦于免疫反应的建立、扩增和记忆阶段亲和力选择的条件。我们推测体细胞突变在亲和力选择之前就已进化，并且我们提出了生发中心B细胞选择的模型。我们还讨论了抗体库在记忆维持阶段发生转变的可能性。最后，我们认为在免疫反应的这个阶段会发生显著的亲和力选择以及对免疫反应多克隆性的选择。
