Di Iorio P, Ballerini P, Caciagli F, Ciccarelli R
Department of Biomedical Sciences, University of Chieti, Italy.
Pharmacol Res. 1998 Mar;37(3):169-78. doi: 10.1006/phrs.1998.0286.
The purpose of this review is to analyse critically our present knowledge on purine release, and in particular the role of these substances as modulators of the nervous transmission. Multiple purine receptor subtypes have been identified, cloned and functionally characterised. Neurons and glial cells are considered to be important sources of extracellular adenine-based purines. The released nucleotides and nucleosides, by interacting with their specific neuronal and glial receptors, activate a complex autocrine and/or paracrine system for the modulation of the release either of neurotransmitters or the purine ones. Guanine-based purines which are released from astrocytes co-operate with adenine-based compounds in this modulation.
本综述的目的是批判性地分析我们目前关于嘌呤释放的知识，尤其是这些物质作为神经传递调节剂的作用。多种嘌呤受体亚型已被鉴定、克隆并进行了功能表征。神经元和神经胶质细胞被认为是细胞外腺嘌呤类嘌呤的重要来源。释放的核苷酸和核苷通过与其特定的神经元和神经胶质受体相互作用，激活一个复杂的自分泌和/或旁分泌系统，以调节神经递质或嘌呤类递质的释放。星形胶质细胞释放的鸟嘌呤类嘌呤在这种调节中与腺嘌呤类化合物协同作用。
