Bree S E, West M J, Taylor P A, Kestin I G
Department of Anaesthesia, Derriford Hospital, Plymouth.
Br J Anaesth. 1998 Feb;80(2):152-4. doi: 10.1093/bja/80.2.152.
We have studied the antiemetic effects of propofol when mixed with morphine in a patient-controlled analgesia (PCA) pump after major gynaecological surgery. In a double-blind, randomized, controlled study, 50 women, ASA I or II, received a standardized anaesthetic comprising thiopental, morphine, atracurium, nitrous oxide and oxygen with enflurane, and received postoperative PCA with morphine mixed with either 1% propofol or lvelip. The PCA bolus was morphine 1 mg with propofol 5 mg or lvelip 0.5 ml, with a lockout time of 5 min. Postoperative nausea and vomiting (PONV) were assessed by the nursing staff using a four-point ordinal scale and by the patient using a visual analogue scale for 48 h after surgery. The two groups were similar in the potential factors influencing the incidence of PONV. There were no significant differences between the two groups in any of the study measurements of PONV. There were, no side effects after propofol. Propofol, when mixed with morphine in this dose combination for PCA, did not decrease the incidence of nausea and vomiting in women undergoing major gynaecological surgery.
我们研究了丙泊酚与吗啡混合于自控镇痛（PCA）泵中在大型妇科手术后的止吐效果。在一项双盲、随机、对照研究中，50名美国麻醉医师协会（ASA）分级为I或II级的女性接受了包含硫喷妥钠、吗啡、阿曲库铵、氧化亚氮和氧气并加恩氟烷的标准化麻醉，并在术后接受了与1%丙泊酚或脂肪乳混合的吗啡PCA。PCA推注剂量为含5mg丙泊酚或0.5ml脂肪乳的1mg吗啡，锁定时间为5分钟。术后恶心呕吐（PONV）由护理人员使用四点序数量表评估，并由患者在术后48小时使用视觉模拟量表评估。两组在影响PONV发生率的潜在因素方面相似。两组在PONV的任何研究测量指标上均无显著差异。丙泊酚使用后无副作用。当以该剂量组合与吗啡混合用于PCA时，丙泊酚并未降低接受大型妇科手术女性的恶心呕吐发生率。
