Montgomery J E, Sutherland C J, Kestin I G, Sneyd J R
Department of Anaesthesia, Derriford Hospital, Plymouth.
Anaesthesia. 1996 Jun;51(6):554-7. doi: 10.1111/j.1365-2044.1996.tb12563.x.
We studied the antiemetic effects of a low dose infusion of propofol for 24 h after major gynaecological surgery in a double-blind, randomised, controlled trial. Fifty women of ASA physical status 1 or 2 undergoing major gynaecological surgery received an infusion of 1% propofol or intralipid at 0.1 ml.kg-1.h-1 for 24 h after surgery. Pain was managed using morphine delivered by a patient-controlled analgesia pump. The degree of postoperative nausea and vomiting was assessed by the nurses using a four-point ordinal scale, by the patients using a visual analogue scale and by the amount of rescue antiemetic given by the nurses. There were no differences between the two groups in any of the measures of postoperative nausea and vomiting during the first 48 h after surgery. Postoperative nausea and vomiting in the control group was less on the second day compared with the first postoperative day, but not in the propofol group. There were no side effects from the propofol infusion.
在一项双盲、随机、对照试验中，我们研究了大剂量妇科手术后低剂量输注丙泊酚24小时的止吐效果。50名美国麻醉医师协会（ASA）身体状况为1或2级的接受大剂量妇科手术的女性，在术后接受了24小时的1%丙泊酚或0.1ml.kg-1.h-1的脂肪乳输注。疼痛通过患者自控镇痛泵给予吗啡进行处理。护士使用四点顺序量表、患者使用视觉模拟量表以及护士给予的抢救性止吐药的量来评估术后恶心和呕吐的程度。在术后的前48小时内，两组在任何术后恶心和呕吐的测量指标上均无差异。与术后第一天相比，对照组术后第二天的恶心和呕吐情况有所减轻，但丙泊酚组并非如此。丙泊酚输注未产生副作用。
