Weidner N
J Pathol. 1998 Feb;184(2):119-22. doi: 10.1002/(SICI)1096-9896(199802)184:2<119::AID-PATH17>3.0.CO;2-D.
Accurate prognostic indicators would help in identifying patients at high risk for recurrence and death. Recent and previous studies indicate that intratumoural microvessel density (iMVD) of invasive breast carcinoma (a measure of tumour angiogenesis) is associated with aggressive tumour growth; iMVD may thus be a valuable prognostic indicator. Moreover, the bulk of accumulating data indicates that microvessel density in the area of most intense neovascularization in invasive breast carcinoma is an independent, significant and accurate prognostic indicator in predicting poorer survival. Such an indicator would be useful in the selection of high-risk patients with breast carcinoma for systemic adjuvant therapy.
准确的预后指标将有助于识别复发和死亡风险高的患者。近期及以往的研究表明，浸润性乳腺癌的瘤内微血管密度（iMVD，一种肿瘤血管生成的测量指标）与肿瘤的侵袭性生长相关；因此，iMVD可能是一个有价值的预后指标。此外，大量积累的数据表明，浸润性乳腺癌中新生血管最密集区域的微血管密度是预测较差生存率的一个独立、显著且准确的预后指标。这样一个指标将有助于选择患有乳腺癌的高危患者进行全身辅助治疗。
