Zhao Jingling, Zhou Fei, Chen Lei, Shu Bin, Zhai Qiyi, Wu Jun, Liu Xusheng, Qi Shaohai, Xu Yingbin
Department of Burns, The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou, China.
Am J Transl Res. 2018 Jan 15;10(1):246-255. eCollection 2018.
Aerosols exist in the form of liquid or solid particles that stably suspending in air. Our previous studies have found that aerosol can accelerate chronic wound healing. However, the biological effects of aerosol in burn wound healing and the underlying molecular mechanism remain unclear. This study aimed to investigate the effects of aerosol on the healing of deep partial-thickness burn wounds and its regulatory mechanisms. By employing a self-controlled model of rats, we demonstrated that aerosol treatment not only increased the healing rate, but also improved the healing quality of deep partial-thickness burn wounds. Besides, the excessive inflammatory responses in the burn wounds were inhibited, and the angiogenesis was increased after aerosol treatment. It did so by upregulating the expression of eNOS/NO, as well as the VGEF expression during the wound healing process. Our results demonstrate that the function of aerosol in promoting burn wound healing is achieved by activating eNOS/NO pathway.
气溶胶以稳定悬浮于空气中的液体或固体颗粒形式存在。我们之前的研究发现，气溶胶可加速慢性伤口愈合。然而，气溶胶在烧伤创面愈合中的生物学效应及其潜在分子机制仍不清楚。本研究旨在探讨气溶胶对深Ⅱ度烧伤创面愈合的影响及其调控机制。通过采用大鼠自身对照模型，我们证明气溶胶治疗不仅提高了愈合率，还改善了深Ⅱ度烧伤创面的愈合质量。此外，气溶胶治疗后烧伤创面过度的炎症反应受到抑制，血管生成增加。其通过上调伤口愈合过程中eNOS/NO的表达以及VGEF的表达来实现。我们的结果表明，气溶胶促进烧伤创面愈合的功能是通过激活eNOS/NO途径实现的。
