Tromme I, Van Neste D, Dobbelaere F, Bouffioux B, Courtin C, Dugernier T, Pierre P, Dupuis M
Department of Dermatology, Clinique Saint Pierre, Ottignies, Belgium.
Br J Dermatol. 1998 Feb;138(2):321-5. doi: 10.1046/j.1365-2133.1998.02083.x.
A 45-year-old man developed a painful and rapidly progressive sensory-motor polyneuropathy associated with confusion and convulsions. This resulted in hypoventilation and led to respiratory failure and coma. A rapid and diffuse alopecia occurred after 3 weeks in the intensive care unit. Examination of hair roots under polarized light detected dystrophic anagen hairs with dark bands caused by empty spaces in the disorganized cortex. These dark zones were originally reported in patients with thallium poisoning and a toxicological investigation confirmed thallium exposure. The classical systemic symptoms and the various dermatological signs are reviewed, and the origins of contamination and physiopathology discussed.
一名45岁男性出现了与意识模糊和惊厥相关的疼痛性、快速进展的感觉运动性多发性神经病。这导致了通气不足，并进而引发呼吸衰竭和昏迷。在重症监护病房3周后出现了快速弥漫性脱发。在偏光显微镜下检查发根发现生长期毛发营养不良，皮质紊乱出现空隙导致毛发出现暗带。这些暗区最初在铊中毒患者中报道过，毒理学调查证实了铊暴露。本文回顾了典型的全身症状和各种皮肤体征，并讨论了污染来源和病理生理学。
