Engelhart D A, Lavins E S, Hazenstab C B, Sutheimer C A
Cuyahoga County Coroner's Office, Cleveland, Ohio 44106, USA.
J Anal Toxicol. 1998 May-Jun;22(3):246-7. doi: 10.1093/jat/22.3.246.
A case in which the death of a 2-year-old male child was the result of an acute intoxication with chloral hydrate, lidocaine, and nitrous oxide is presented. Trichloroethanol (TCE), the primary metabolite of chloral hydrate, was qualitatively detected by the Fujiwara reaction. Quantitation of TCE was carried out by gas chromatography-mass spectrometry (GC-MS) with the following results: plasma, 79.0 mg/L; urine, 31.0 mg/L; gastric contents, 454.0 mg/L; bile, 111.0 mg/L; vitreous, 40.2 mg/L; cerebrospinal fluid (CSF), 68.3 mg/L; and liver, 164 mg/kg. Lidocaine was quantitated by GC analysis using nitrogen-phosphorus detection with the following results: plasma, 11.9 mg/L; urine, 3.7 mg/L; gastric contents, 15.3 mg/L; bile, 19.0 mg/L; vitreous, 17.8 mg/L; CSF, 9.4 mg/L; and liver, 19.0 mg/kg. Nitrous oxide was quantitated in the blood with a value of 4.4 mL/L.
本文报告了一例2岁男童因水合氯醛、利多卡因和氧化亚氮急性中毒死亡的病例。通过藤原反应定性检测了水合氯醛的主要代谢产物三氯乙醇（TCE）。采用气相色谱-质谱联用（GC-MS）对TCE进行定量分析，结果如下：血浆中79.0 mg/L；尿液中31.0 mg/L；胃内容物中454.0 mg/L；胆汁中111.0 mg/L；玻璃体液中40.2 mg/L；脑脊液（CSF）中68.3 mg/L；肝脏中164 mg/kg。采用氮磷检测的GC分析法定量利多卡因，结果如下：血浆中11.9 mg/L；尿液中3.7 mg/L；胃内容物中15.3 mg/L；胆汁中19.0 mg/L；玻璃体液中17.8 mg/L；脑脊液中9.4 mg/L；肝脏中19.0 mg/kg。血液中氧化亚氮的定量值为4.4 mL/L。
