Billotte W G, Bajpai P K
Biology Department, University of Dayton, Ohio 45469-2320, USA.
Biomed Sci Instrum. 1997;34:13-7.
Dexamethasone has been shown to stimulate bone nodule formation in vitro. A hydroxyapatite (HA) reservoir drug release device was designed to release dexamethasone in vitro. Two HA particle sizes (< 38 microns or 63-75 microns) were used to fabricate the reservoirs. Each HA reservoir was loaded with 2 mg of dexamethasone and suspended in 100 ml of 50% aqueous ethanol at 37 degrees C for a period of 28 days. The positive controls indicated a limited solubility of dexamethasone of 1.18 mg per 100 ml of 50% aqueous ethanol. Dexamethasone was not released from any of the HA reservoirs for the first 24 hours. The largest amount of dexamethasone (0.0137 microgram/microliter) was released from the 63-75 microns particle HA reservoirs. A significantly lesser amount (0.00855 microgram/microliter) of dexamethasone was released from the < 38 microns particle HA reservoirs. The results of this study suggest that a HA ceramic reservoir loaded with dexamethasone can be used to deliver dexamethasone over long periods of time.
已证明地塞米松在体外能刺激骨结节形成。设计了一种羟基磷灰石（HA）储库型药物释放装置用于地塞米松的体外释放。使用两种HA粒径（<38微米或63 - 75微米）来制备储库。每个HA储库装载2毫克地塞米松，并于37℃下悬浮在100毫升50%乙醇水溶液中28天。阳性对照表明地塞米松在每100毫升50%乙醇水溶液中的溶解度有限，为1.18毫克。在最初24小时内，地塞米松未从任何HA储库中释放。从63 - 75微米粒径的HA储库中释放出的地塞米松量最大（0.0137微克/微升）。从<38微米粒径的HA储库中释放出的地塞米松量明显较少（0.00855微克/微升）。本研究结果表明，装载地塞米松的HA陶瓷储库可用于长时间递送地塞米松。
