Tscholl B, Billotte W G, Reed D, Smith S, Kreinbrink K, Bajpai P K
Department of Biology, University of Dayton, OH 45469, USA.
Biomed Sci Instrum. 1997;34:70-5.
Various studies have been conducted using hydroxyapatite (HA) to deliver therapeutic drugs over a long period of time. However, the rate of drug release from ceramics varies tremendously. Thus a study was designed to observe the effect of particle size, pressure, drug ratio, and the addition of a zinc stearate binder on the release of BSA from ceramics. Samples were collected every two hours for a 12 hour period. Three particle sizes were used in the study (< 38, 45-63, and 63-75 microns). Variations in particle size did not influence the release of BSA. Ceramics compressed at a pressure of 150 Mpa delivered more protein than pressures of 300 MPa, 450 MPa, and 900 MPa. Drug to ceramic ratio had the most significant effect. A ratio of 1:25 BSA to HA delivered the protein quickly whereas the 1:100 BSA to HA delivered BSA to HA delivered BSA slowly and in zero order kinetics. The addition of the zinc binder improved the quality of the composite and decreased the release rate of protein delivery when present in 5% or less of the total ceramic weight. HA ceramics can be used to deliver proteins at different rates by varying compression pressure and drug to HA ratio.
已经进行了各种使用羟基磷灰石（HA）来长时间递送治疗药物的研究。然而，药物从陶瓷中的释放速率差异极大。因此，设计了一项研究来观察粒径、压力、药物比例以及添加硬脂酸锌粘合剂对BSA从陶瓷中释放的影响。在12小时内每两小时收集一次样品。该研究使用了三种粒径（<38、45 - 63和63 - 75微米）。粒径的变化并未影响BSA的释放。在150兆帕压力下压制的陶瓷比300兆帕、450兆帕和900兆帕压力下压制的陶瓷释放出更多的蛋白质。药物与陶瓷的比例影响最为显著。BSA与HA的比例为1:25时能快速释放蛋白质，而BSA与HA的比例为1:100时则缓慢释放BSA且呈零级动力学。当锌粘合剂的添加量占陶瓷总重量的5%或更少时，它能改善复合材料的质量并降低蛋白质递送的释放速率。通过改变压制压力以及药物与HA的比例，HA陶瓷可用于以不同速率递送蛋白质。
