Reed D, Billotte W G, Rush B J, Odorzynski A, Kreinbrink K, Bajpai P K
Department of Biology, University of Dayton, OH 45409, USA.
Biomed Sci Instrum. 1997;34:59-64.
Hydroxyapatite (HA) has been used to deliver therapeutic drugs both in vitro and in vivo at a constant rate showing zero order kinetics. This study was designed specifically to analyze the effects of wheat germ (WG) incorporation with HA on the rate of delivery of AZT from an insert system over a one month period in vitro. Insert systems which were saturated with wheat germ oil delivered AZT at a slower rate over the one month period than did half-saturated or unsaturated insert systems. All systems containing 50 mg of AZT in the outer shell delivered 80% of the 100 mg AZT dosage over the first eight days. The systems which had a 100 mg AZT insert surrounded by an oily HA shell lacking AZT delivered AZT in a linear manner over the course of one month. The amounts and rates of AZT release from composites was indirectly proportional to the amount of wheat germ oil used. The results of this study show that the lipids incorporated in the ceramic composites can be tailored to deliver a 100 mg AZT dosage for a period of one month in vitro.
羟基磷灰石（HA）已被用于在体外和体内以零级动力学的恒定速率递送治疗药物。本研究专门设计用于分析在体外一个月的时间内，将小麦胚芽（WG）与HA结合对从插入系统中递送齐多夫定（AZT）速率的影响。用小麦胚芽油饱和的插入系统在一个月内递送AZT的速率比半饱和或不饱和插入系统慢。所有外壳中含有50 mg AZT的系统在头八天内递送了100 mg AZT剂量的80%。具有100 mg AZT插入物并被不含AZT的油性HA外壳包围的系统在一个月的时间内以线性方式递送AZT。AZT从复合材料中的释放量和释放速率与所用小麦胚芽油的量成反比。本研究结果表明，陶瓷复合材料中掺入的脂质可以进行调整，以便在体外一个月的时间内递送100 mg AZT剂量。
