Kapelushnik J, Aker M, Pugatsch T, Samuel S, Slavin S
Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
Bone Marrow Transplant. 1998 Apr;21(8):857-8. doi: 10.1038/sj.bmt.1701165.
A 2.5-year-old girl with neurogenic Gaucher's disease was transplanted with donor bone marrow from her HLA-compatible 12-year-old brother whose marrow was harvested 30 min post-mortem, after he suffered a severe head and neck injury. The marrow was stored in liquid nitrogen for 30 days prior to infusion. The post-transplantation period was uneventful with good engraftment and no signs of graft-versus-host disease. Currently, 6 months post-allogeneic bone marrow transplantation (alloBMT), analysis of both bone marrow and blood samples by PCR documented only cells of donor origin. This case demonstrates the feasibility of cadaveric marrow as a source of donor cells. To our knowledge, this patient is the only survivor of alloBMT from a cadaveric donor.
一名患有神经源性戈谢病的2.5岁女孩接受了来自其12岁哥哥的供体骨髓移植，其哥哥在遭受严重头颈部损伤后于死后30分钟采集了骨髓。骨髓在输注前于液氮中保存了30天。移植后过程顺利，植入良好，无移植物抗宿主病迹象。目前，在异基因骨髓移植（alloBMT）6个月后，通过PCR对骨髓和血液样本进行分析，结果仅显示为供体来源的细胞。该病例证明了尸体骨髓作为供体细胞来源的可行性。据我们所知，该患者是来自尸体供体的alloBMT的唯一幸存者。
