Furlong R A, Coleman T A, Ho L, Rubinsztein J S, Walsh C, Paykel E S, Rubinsztein D C
Department of Medical Genetics, University of Cambridge, Addenbrooke's Hospital, UK.
Am J Med Genet. 1998 Sep 7;81(5):385-7.
The dopaminergic system, along with the serotonergic and noradrenergic systems, has been implicated in the etiology of mood disorders. An association study of a functional variant in the promoter region of the dopamine D2 receptor (DRD2) with bipolar affective disorder I or unipolar major affective disorders was performed. Variable expression of the DRD2 gene in vitro has been shown with this promoter polymorphism. One hundred and thirty-one unrelated bipolar patients, 128 unrelated unipolar patients, and 262 controls were used in the study. There were no significant differences in DRD2 allele or genotype frequencies between the affective disorder and control groups. These results do not support a major role for the DRD2 gene in the etiology of either bipolar or unipolar affective disorders.
多巴胺能系统与血清素能系统和去甲肾上腺素能系统一样，被认为与情绪障碍的病因有关。对多巴胺D2受体（DRD2）启动子区域的一个功能变体与I型双相情感障碍或单相重度情感障碍进行了关联研究。该启动子多态性已显示出DRD2基因在体外的可变表达。本研究使用了131名无亲缘关系的双相情感障碍患者、128名无亲缘关系的单相情感障碍患者和262名对照。情感障碍组和对照组之间的DRD2等位基因或基因型频率没有显著差异。这些结果不支持DRD2基因在双相或单相情感障碍病因中起主要作用。
