培养条件控制寄生曲霉和构巢曲霉中黄曲霉毒素和柄曲霉素生物合成基因的表达。
Culture conditions control expression of the genes for aflatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and A. nidulans.
作者信息
Feng G H, Leonard T J
机构信息
Department of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA.
出版信息
Appl Environ Microbiol. 1998 Jun;64(6):2275-7. doi: 10.1128/AEM.64.6.2275-2277.1998.
Abstract
High temperature and nitrate supported gene expression for sterigmatocystin biosynthesis in Aspergillus nidulans; ammonium did not. Homologous genes for aflatoxin biosynthesis in A. parasiticus showed the opposite transcript expression pattern, suggesting that the two mycotoxins are regulated differently. The aflR gene is postulated to require additional genetic elements to effect its own activation by the different culture conditions. A patulin polyketide synthase (PKS) gene was found to be regulated differently than the aflatoxin PKS. Thus, the biosyntheses of structurally similar compounds in these two fungi appear to be regulated very differently.
摘要
高温和硝酸盐支持构巢曲霉中用于合成柄曲霉素的基因表达；铵则不然。寄生曲霉中黄曲霉毒素生物合成的同源基因表现出相反的转录表达模式，这表明这两种霉菌毒素的调控方式不同。据推测，aflR基因需要额外的遗传元件才能在不同培养条件下实现自身激活。发现展青霉素聚酮合酶（PKS）基因的调控方式与黄曲霉毒素PKS不同。因此，这两种真菌中结构相似化合物的生物合成似乎受到非常不同的调控。
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本文引用的文献
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Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus.构巢曲霉和黄曲霉中黄曲霉毒素调控基因aflR的结构与功能保守性
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