West D J, Andrews E B, McVean A R, Thorndyke M C, Taylor J D
School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, U.K.
Toxicon. 1998 Jan;36(1):25-9. doi: 10.1016/s0041-0101(97)00116-5.
Presence of a toxin in the salivary glands of the marine snail Cymatium intermedius that targets nicotinic acetylcholine receptors. Toxicon 36, 25-29, 1998.-We present evidence of a neurotoxin from the salivary glands of Cymatium intermedius that displays acetylcholine-like effects on vertebrate (mouse ileum) and invertebrate (molluscan smooth muscle; molluscan heart; leech body wall) tissues. These effects were completely blocked by (+)-tubocurarine (10-100 muM) but not by atropine (up to 200 muM) suggesting that the toxin targets nicotinic-like acetylcholine receptors. This affirms the proposal that this genus may overcome their prey with a paralytic secretion.
在中东风螺（Cymatium intermedius）唾液腺中存在一种靶向烟碱型乙酰胆碱受体的毒素。《毒素学》，第36卷，第25 - 29页，1998年。——我们提供了来自中东风螺唾液腺的一种神经毒素的证据，该毒素对脊椎动物（小鼠回肠）和无脊椎动物（软体动物平滑肌；软体动物心脏；水蛭体壁）组织表现出类乙酰胆碱作用。这些作用被（+） - 筒箭毒碱（10 - 100 μM）完全阻断，但不被阿托品（高达200 μM）阻断，这表明该毒素靶向类烟碱型乙酰胆碱受体。这证实了关于该属可能通过麻痹性分泌物制服其猎物的提议。
