Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Qld, Australia.
Mar Drugs. 2018 Apr 5;16(4):118. doi: 10.3390/md16040118.
A diverse range of predatory marine gastropods produce toxins, yet most of these molecules remain uncharacterized. species have received the most attention from researchers, leading to several conopeptides reaching clinical trials. This review aims to summarize what is known about bioactive compounds isolated from species of neglected marine gastropods, especially in the Turridae, Terebridae, Babyloniidae, Muricidae, Buccinidae, Colubrariidae, Nassariidae, Cassidae, and Ranellidae families. Multiple species have been reported to contain bioactive compounds with potential toxic activity, but most of these compounds have not been characterized or even clearly identified. The bioactive properties and potential applications of echotoxins and related porins from the Ranellidae family are discussed in more detail. Finally, the review concludes with a call for research on understudied species.
多种多样的掠食性海洋腹足纲动物会产生毒素，但这些分子大多数仍未被描述。其中一些物种受到了研究人员的最多关注，导致几种芋螺肽进入临床试验。本综述旨在总结从被忽视的海洋腹足纲动物物种中分离出的生物活性化合物的已知情况，特别是在宝贝科、骨螺科、芋螺科、宝螺科、织纹螺科、Colubrariidae 科、芋螺科、榧螺科和 Cassidae 科。有报道称多种物种含有具有潜在毒性活性的生物活性化合物，但其中大多数化合物尚未被描述甚至尚未明确鉴定。更详细地讨论了来自芋螺科的 echotoxins 和相关 porins 的生物活性特性和潜在应用。最后，综述呼吁对研究较少的物种进行研究。
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