Gun R T, Seymour A E, Mathew T H
Department of Public Health, University of Adelaide, South Australia.
Occup Med (Lond). 1998 Jan;48(1):59-62. doi: 10.1093/occmed/48.1.59.
In a pesticide manufacturing and formulating facility, 10 employees out of 48 were shown to have haematuria on dipstick testing. They included seven of the 27 production workers, all of whom had worked in both of two particular areas prior to the commencement of the routine urine testing. Five of the seven production workers with haematuria underwent further investigations, and in all five the haematuria was glomerular in origin. Two underwent renal biopsy, which showed irregular attenuation of the glomerular basement membrane (GBM) but no abnormality by light microscopy. Immunofluorescence studies were negative. This case series of glomerular haematuria is not readily explained by chance, false positive dipstick testing, or a recognizable non-occupational cause. Thin GBM disease, which is a benign condition, appears the likely explanation. Thin GBM disease is usually an autosomal dominant condition, but clustering of these genotypes in this small population is improbable.
在一家农药生产和制剂工厂，48名员工中有10名经试纸检测显示有血尿。其中包括27名生产工人中的7名，在常规尿液检测开始前，他们都曾在两个特定区域工作过。7名有血尿的生产工人中有5名接受了进一步检查，所有5人的血尿均源于肾小球。其中2人进行了肾活检，结果显示肾小球基底膜（GBM）不规则变薄，但光学显微镜检查未发现异常。免疫荧光研究为阴性。这一系列肾小球血尿病例不太可能是偶然、试纸检测假阳性或可识别的非职业性原因所致。薄基底膜肾病是一种良性疾病，似乎是可能的解释。薄基底膜肾病通常为常染色体显性疾病，但在这个小群体中这些基因型聚集的可能性不大。
