Mahadevan M M, Miller M M, Maris M O, Moutos D
UAMS Department of Obstetrics & Gynecology, USA.
J Ark Med Soc. 1998 May;94(12):529-31.
In vitro fertilization and embryo transfer (IVF) is utilized as a treatment for infertile couples who cannot conceive with standard therapy. Assisted hatching (AH) is a procedure whereby an opening is made in the zona pellucida of the embryos, thereby increasing the probability of implantation and pregnancy. AH is beneficial in patients with elevated FSH levels, older than age 38 or those who failed IVF repeatedly. Success rates after IVF with AH at the University of Arkansas for Medical Sciences (UAMS) compares favorably with rates achieved by other centers in the USA. Pregnancy rates after IVF with AH in patients older than 38 years is approximately 20% compared to a pregnancy rate of 10% in patients who did not have AH. This report summarizes the UAMS experience with IVF and AH.
体外受精与胚胎移植（IVF）被用作无法通过标准疗法受孕的不育夫妇的一种治疗方法。辅助孵化（AH）是一种在胚胎的透明带上开口的操作，从而增加着床和怀孕的概率。AH对促卵泡生成素（FSH）水平升高、年龄超过38岁或多次IVF失败的患者有益。阿肯色大学医学科学分校（UAMS）进行的AH-IVF后的成功率与美国其他中心取得的成功率相比具有优势。38岁以上患者进行AH-IVF后的妊娠率约为20%，而未进行AH的患者妊娠率为10%。本报告总结了UAMS在IVF和AH方面的经验。
