Rosenstock S J, Andersen L P, Rosenstock C V, Bonnevie O, Jørgensen T
Center for Sygdomsforebyggelse, Amtssygehuset i Glostrup.
Ugeskr Laeger. 1998 Mar 30;160(14):2109-15.
The aim of this study was to examine the relationship between housing conditions, educational level, occupational factors, and serologically diagnosed acute and chronic Helicobacter pylori infection. IgG, IgM, and IgA antibodies against Helicobacter pylori were measured by ELISA techniques in sera obtained from a random sample of 3589 Danes participating in a population study. Poor social status (odds ratio 2.2 [1.7-3.0]), short duration of schooling (odds ratio 2.0 [1.3-2.5]), lack of vocational training/education (odds ratio 1.4 [1.2-1.7]), unskilled work (odds ratio 1.7 [1.2-2.5]), and high work-related energy expenditure (odds ratio 1.4 [1.1-1.9]) increased the likelihood of chronic Helicobacter pylori infection. Chronic Helicobacter pylori infection was frequently found in people with a history of living abroad. Increased levels solely of IgM antibodies to H. pylori, interpreted as a sign of acute infection, were found more often in people who were divorced (odds ratio 2.3 [1.2-4.4]) or unmarried (odds ratio 2.0 [1.1-3.8]) and in people who worked long hours (odds ratio 2.0 [1.1-4.0]). In conclusion, educational and occupational factors relate to the likelihood of chronic Helicobacter pylori infection in adults. The rate of acute Helicobacter pylori infection is probably increased in single adults.
本研究的目的是探讨居住条件、教育水平、职业因素与血清学诊断的急性和慢性幽门螺杆菌感染之间的关系。采用酶联免疫吸附测定(ELISA)技术,对参与一项人群研究的3589名丹麦人的随机样本血清中抗幽门螺杆菌的IgG、IgM和IgA抗体进行了检测。社会地位低下(比值比2.2 [1.7 - 3.0])、受教育时间短(比值比2.0 [1.3 - 2.5])、缺乏职业培训/教育(比值比1.4 [1.2 - 1.7])、非技术工作(比值比1.7 [1.2 - 2.5])以及与工作相关的高能量消耗(比值比1.4 [1.1 - 1.9])会增加慢性幽门螺杆菌感染的可能性。慢性幽门螺杆菌感染在有国外生活史的人群中很常见。仅抗幽门螺杆菌IgM抗体水平升高(被视为急性感染的迹象)在离婚者(比值比2.3 [1.2 - 4.4])或未婚者(比值比2.0 [1.1 - 3.8])以及长时间工作的人群(比值比2.0 [1.1 - 4.0])中更常见。总之,教育和职业因素与成年人慢性幽门螺杆菌感染的可能性有关。单身成年人急性幽门螺杆菌感染率可能会增加。