• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis of new N-substituted benzodiazepine derivatives with potential anxiolytic activity.

作者信息

Kossakowski J, Zawadowski T, Turło J

机构信息

Department of Medical Chemistry, Medical University of Warsaw, Poland.

出版信息

Acta Pol Pharm. 1997 Nov-Dec;54(6):483-5.

PMID:9604696
Abstract

In continuation of the development of antipsychotic and anxiolytic agents with a reduced propensity toward extrapyramidal side-effects, a series of N-aminoalkyl derivatives of (s)-(+)-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H, 11aH)-dione was prepared. Evaluation of these compounds in revealed a very low affinity for 5-HT1A receptor.

摘要

相似文献

1
Synthesis of new N-substituted benzodiazepine derivatives with potential anxiolytic activity.
Acta Pol Pharm. 1997 Nov-Dec;54(6):483-5.
2
Synthesis and receptor binding studies of 2-functionalized 1,4-benzodiazepine derivatives as potential metaclazepam-like antianxiety agents.2-官能化1,4-苯二氮䓬衍生物作为潜在的类似美他西泮抗焦虑剂的合成及受体结合研究
Farmaco. 1993 Jul;48(7):897-905.
3
Synthesis of N,N'-bis-aminoalkyl-substituted derivatives of bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxydiimide with potential anxiolytic activity.具有潜在抗焦虑活性的双环[2.2.2]辛-7-烯-2,3,5,6-四羧酸二亚胺的N,N'-双氨基烷基取代衍生物的合成。
Farmaco. 1996 Dec;51(12):815-8.
4
[Studies on substances with antiblastic activity. IX. Anthramycin and analogs. IX. Synthesis of 7-methoxy-8-hydroxy-10,11-dihydro-5H-pyrrolo[2,1-c] [1,4] benzodiazepine and other compounds related to oxotomaymycin].
Farmaco Sci. 1977 Aug;32(8):579-92.
5
Synthesis, structure and affinity of novel 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones for CNS central and peripheral benzodiazepine receptors.新型 3-烷氧基-1,2-二氢-3H-1,4-苯并二氮杂卓-2-酮类化合物的合成、结构与中枢及外周苯二氮䓬受体亲和力。
Eur J Med Chem. 2010 Apr;45(4):1346-51. doi: 10.1016/j.ejmech.2009.12.027. Epub 2009 Dec 22.
6
Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.苯二氮䓬受体配体。8：新型3,8-二取代吡唑并[5,1-c][1,2,4]苯并三嗪5-氧化物的合成与药理评价：具有反向激动剂药理活性的高亲和力配体。
Bioorg Med Chem. 2006 Feb 1;14(3):758-75. doi: 10.1016/j.bmc.2005.08.058. Epub 2005 Oct 7.
7
Synthesis of some n-substituted derivatives of 1-(1h-pyrrole-1 -ylmethyl)- 10-oxa-4-azatricyclo [5.2.1.0(2,6)]dec-8-ene-3,5-dione with an expected anxiolytic activity.具有预期抗焦虑活性的一些1-(1H-吡咯-1-基甲基)-10-氧杂-4-氮杂三环[5.2.1.0(2,6)]癸-8-烯-3,5-二酮的N-取代衍生物的合成。
Acta Pol Pharm. 2006 Sep-Oct;63(5):424-6.
8
Synthesis and pharmacological activity of 1,4-benzodiazepine derivatives.1,4-苯二氮䓬衍生物的合成及药理活性
Boll Chim Farm. 2002 Jan-Feb;141(1):8-14.
9
Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides.苯二氮䓬受体配体。4. 3-杂芳基-8-氯吡唑并[5,1-c][1,2,4]苯并三嗪5-氧化物的合成与药理评价。
J Med Chem. 1999 Jun 17;42(12):2218-26. doi: 10.1021/jm981126y.
10
Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. VIII-Synthesis and inhibition of benzodiazepine receptor binding of some derivatives of triazino[3,4-c]-1,4-benzothiazine and triazino[3,4-d]-1,5-benzothiazepine, two new heterocyclic ring systems.稠合1,4 - 苯并噻嗪和1,5 - 苯并硫氮杂䓬的研究。VIII - 三嗪并[3,4 - c]-1,4 - 苯并噻嗪和三嗪并[3,4 - d]-1,5 - 苯并硫氮杂䓬两种新杂环体系的一些衍生物的合成及其对苯二氮䓬受体结合的抑制作用
Farmaco. 1994 Apr;49(4):245-51.