Nakahara Y, Murata M, Suzuki T, Ohtsu F, Nagasawa K
Int J Clin Pharmacol Res. 1998;18(1):1-11.
Depending on the administration method, highly effective therapeutic variable serum concentrations (VSC) of theophylline can be attained only in the time range of frequent asthma attacks. We used an oral sustained-release theophylline preparation in seven patients with bronchial asthma (two males and five females; mean age: 38.7 years) who had required more than two admissions per year due to bronchial asthma attacks, despite being treated with round-the-clock (RTC) therapy of theophylline and inhalation of steroids. We examined the annual frequency of admissions and the peak expiratory flow rate (PEFR) in remission. Even though no difference was noted in the serum concentrations of theophylline in the morning (the time range of attack) between RTC therapy and VSC therapy, the mean number of admissions during VSC therapy was 1.14, compared with 3.86 recorded during RTC therapy (p < 0.001). PEFR in remission showed a significant improvement with VSC therapy, compared with PEFR recorded during RTC therapy (p < 0.05). VSC therapy proved to be useful for patients who failed to attain favorable control of asthma attacks by RTC therapy.
根据给药方式的不同，只有在频繁哮喘发作的时间段内才能达到高效治疗所需的茶碱可变血清浓度（VSC）。我们对7例支气管哮喘患者（2例男性，5例女性；平均年龄：38.7岁）使用了口服缓释茶碱制剂，这些患者尽管接受了茶碱全天候（RTC）治疗和吸入类固醇治疗，但每年仍因支气管哮喘发作而需要住院两次以上。我们检查了每年的住院频率以及缓解期的呼气峰值流速（PEFR）。尽管RTC治疗和VSC治疗在早晨（发作时间段）的茶碱血清浓度上没有差异，但VSC治疗期间的平均住院次数为1.14次，而RTC治疗期间记录的为3.86次（p < 0.001）。与RTC治疗期间记录的PEFR相比，VSC治疗使缓解期的PEFR有显著改善（p < 0.05）。事实证明，VSC治疗对那些通过RTC治疗未能有效控制哮喘发作的患者有用。
