Otero M J, Barrueco M, Mariño E, Gomez F, Dominguez-Gil A
Int J Clin Pharmacol Ther Toxicol. 1987 Mar;25(3):157-62.
The efficacy of maintenance theophylline therapy at serum concentrations ranging between 8 and 20 micrograms/ml was studied over a six-month period in a group of 100 outpatients (age range 18-80 years) with chronic asthma. The study was satisfactorily completed by 95 of the individuals. Theophylline therapy led to a progressive disappearance of the patients' clinical signs and symptoms. A significant improvement in pulmonary function was observed in all patients, which was related to the initial degree of airway obstruction. The improvement was more pronounced at the start of treatment. At the end of the study there were still anomalies in the respiratory parameters in those patients who originally showed greater pulmonary compromise (FEV1 less than 50% of the predicted value) which seemed to indicate persistent airway obstruction. However, the improvement shown by these patients was sufficient for them to carry out their normal daily activities. We conclude that controlled long-term therapy with theophylline may be beneficial for outpatients with chronic asthma.
在一组100名（年龄范围18 - 80岁）患有慢性哮喘的门诊患者中，对血清浓度在8至20微克/毫升之间的维持性茶碱治疗的疗效进行了为期六个月的研究。100名个体中有95名圆满完成了研究。茶碱治疗使患者的临床体征和症状逐渐消失。所有患者的肺功能均有显著改善，这与气道阻塞的初始程度有关。治疗开始时改善更为明显。在研究结束时，那些最初肺功能受损更严重（第一秒用力呼气容积低于预测值的50%）的患者的呼吸参数仍存在异常，这似乎表明存在持续性气道阻塞。然而，这些患者所表现出的改善足以使他们能够进行正常的日常活动。我们得出结论，茶碱的长期控制性治疗可能对慢性哮喘门诊患者有益。
