排除肝细胞核因子4α作为与20号染色体相关的晚发性非胰岛素依赖型糖尿病候选基因。 - Suppr

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超能文献

Exclusion of the hepatocyte nuclear factor 4alpha as a candidate gene for late-onset NIDDM linked with chromosome 20q.

作者信息

Malecki M T, Antonellis A, Casey P, Ji L, Wantman M, Warram J H, Krolewski A S

机构信息

Joslin Diabetes Center, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.

出版信息

Diabetes. 1998 Jun;47(6):970-2. doi: 10.2337/diabetes.47.6.970.

DOI:10.2337/diabetes.47.6.970

PMID:9604877

Abstract

摘要

相似文献

Exclusion of the hepatocyte nuclear factor 4alpha as a candidate gene for late-onset NIDDM linked with chromosome 20q.排除肝细胞核因子4α作为与20号染色体相关的晚发性非胰岛素依赖型糖尿病候选基因。

Diabetes. 1998 Jun;47(6):970-2. doi: 10.2337/diabetes.47.6.970.

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.位于20号染色体上的肝细胞核因子4α基因上游启动子区域的一种常见多态性与2型糖尿病相关，并且似乎为阿什肯纳兹犹太人群体中的连锁证据提供了支持。

Diabetes. 2004 Apr;53(4):1134-40. doi: 10.2337/diabetes.53.4.1134.

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.2型糖尿病：716对芬兰患病同胞对中20号染色体连锁的证据。

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2198-203. doi: 10.1073/pnas.96.5.2198.

Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.在日本患病同胞对中进行的全基因组2型糖尿病搜索，证实了3号染色体长臂、15号染色体长臂和20号染色体长臂上的易感基因，并在7号染色体短臂和11号染色体短臂上鉴定出两个新的候选基因座。

Diabetes. 2002 Apr;51(4):1247-55. doi: 10.2337/diabetes.51.4.1247.

A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.肝细胞核因子-4α中的一个错义突变，导致转录激活活性降低，与人类晚发性非胰岛素依赖型糖尿病有关。

J Clin Invest. 1998 Feb 1;101(3):521-6. doi: 10.1172/JCI1403.

Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4alpha in Caucasians with maturity onset NIDDM.对成年起病的非胰岛素依赖型糖尿病白种人中肝细胞核因子-4α编码区基因变异性的研究。

Diabetologia. 1997 Aug;40(8):980-3. doi: 10.1007/s001250050778.

Mutations in the hepatocyte nuclear factor-4alpha gene in Japanese with non-insulin-dependent diabetes: a nucleotide substitution in the polypyrimidine tract of intron 1b.日本非胰岛素依赖型糖尿病患者肝细胞细胞核因子-4α基因的突变：内含子1b多嘧啶序列中的一个核苷酸替换。

Horm Metab Res. 2000 Aug;32(8):316-20. doi: 10.1055/s-2007-978643.

Maturity-onset diabetes of the young caused by a balanced translocation where the 20q12 break point results in disruption upstream of the coding region of hepatocyte nuclear factor-4alpha (HNF4A) gene.

Diabetes. 2002 Jul;51(7):2329-33. doi: 10.2337/diabetes.51.7.2329.

Mutations in the genes for hepatocyte nuclear factor (HNF)-1alpha, -4alpha, -1beta, and -3beta; the dimerization cofactor of HNF-1; and insulin promoter factor 1 are not common causes of early-onset type 2 diabetes in Pima Indians.肝细胞细胞核因子（HNF）-1α、-4α、-1β和-3β基因；HNF-1的二聚化辅助因子；以及胰岛素启动因子1的突变并非皮马印第安人早发型2型糖尿病的常见病因。

Diabetes Care. 2000 Mar;23(3):302-4. doi: 10.2337/diacare.23.3.302.

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.在英国白种人中，未发现12号和20号染色体上2型糖尿病候选易感基因座存在连锁的证据。

J Clin Endocrinol Metab. 2000 Feb;85(2):853-7. doi: 10.1210/jcem.85.2.6395.

引用本文的文献

Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youth.法裔加拿大青年中的肝细胞核因子4α基因多态性与代谢综合征

PLoS One. 2015 Feb 11;10(2):e0117238. doi: 10.1371/journal.pone.0117238. eCollection 2015.

Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial.肝细胞核因子4α基因的单核苷酸多态性与2型糖尿病的转化相关：STOP-NIDDM试验

J Mol Med (Berl). 2006 Aug;84(8):701-8. doi: 10.1007/s00109-006-0063-3. Epub 2006 Jul 13.

The role of HNF4A variants in the risk of type 2 diabetes.肝细胞核因子4A变体在2型糖尿病风险中的作用。

Curr Diab Rep. 2005 Apr;5(2):149-56. doi: 10.1007/s11892-005-0043-y.

Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population.肝细胞核因子4α启动子常见多态性对法国白种人群2型糖尿病易感性的影响。

Diabetologia. 2005 Mar;48(3):440-4. doi: 10.1007/s00125-004-1665-3. Epub 2005 Feb 25.

Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population.肝细胞细胞核因子（HNF）-4α基因附近的变异与丹麦人群中的2型糖尿病相关。

Diabetologia. 2005 Mar;48(3):452-8. doi: 10.1007/s00125-005-1671-0. Epub 2005 Feb 25.

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.2型糖尿病的候选基因关联研究表明，参与β细胞功能以及胰岛素作用的基因发挥了作用。

PLoS Biol. 2003 Oct;1(1):E20. doi: 10.1371/journal.pbio.0000020. Epub 2003 Oct 13.

T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects.肝细胞核因子4α（HNF-4α）基因中的T130I突变是肝细胞中的功能丧失性突变，与日本受试者的迟发性2型糖尿病相关。

Diabetologia. 2003 Apr;46(4):567-73. doi: 10.1007/s00125-003-1067-y. Epub 2003 Mar 25.

Newly defined genetic diabetes syndromes: maturity onset diabetes of the young.新定义的遗传性糖尿病综合征：青少年成年起病型糖尿病。

Rev Endocr Metab Disord. 2003 Mar;4(1):43-51. doi: 10.1023/a:1021823419393.

A genomewide search for type 2 diabetes-susceptibility genes in indigenous Australians.在澳大利亚原住民中进行全基因组范围的2型糖尿病易感基因搜索。

Am J Hum Genet. 2002 Feb;70(2):349-57. doi: 10.1086/338626. Epub 2001 Dec 12.

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.2型糖尿病：716对芬兰患病同胞对中20号染色体连锁的证据。

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2198-203. doi: 10.1073/pnas.96.5.2198.

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