Shulman L P, Briggs R, Phillips O P, Friedman S A, Sibai B
Department of Obstetrics and Gynecology, University of Tennessee at Memphis, 38103-2896, USA.
Fetal Diagn Ther. 1998 Jan-Feb;13(1):26-8. doi: 10.1159/000020796.
The obstetrical management of women with renal disease is complicated and associated with increased fetal and maternal morbidity. However, maternal serum screening is an integral part of obstetrical care and should be offered to all women. We found that maternal serum levels of a-fetoprotein and human chorionic gonadotropin did not significantly change as a result of hemodialysis, whereas levels of unconjugated estriol were markedly decreased following hemodialysis. Maternal serum screening should be limited to alpha-fetoprotein analysis in women undergoing hemodialysis until the effects of hemodialysis on all serum analytes are better delineated.
患有肾病的女性的产科管理很复杂，且与胎儿和产妇发病率增加相关。然而，母体血清筛查是产科护理的一个组成部分，应该提供给所有女性。我们发现，甲胎蛋白和人绒毛膜促性腺激素的母体血清水平不会因血液透析而显著变化，而未结合雌三醇水平在血液透析后明显降低。在血液透析对所有血清分析物的影响得到更好的描述之前，母体血清筛查应仅限于接受血液透析的女性的甲胎蛋白分析。
