Pozzilli P
Libero Istituto Universitario, Campus Biomedico, Rome, Italy.
Diabetes Metab Rev. 1998 Mar;14(1):69-84. doi: 10.1002/(sici)1099-0895(199803)14:1<69::aid-dmr203>3.0.co;2-e.
Recent advances in the understanding of the pathogenesis of insulin-dependent diabetes mellitus (IDDM) have led to the first trials of disease prevention in susceptible individuals. Two main trials (nicotinamide and insulin) are now running but first results will not be available before the turn of the century. Pilot trials using different approaches, most of them based on the induction of immunotolerance, are also under way and should offer new insight for establishing larger multicentre studies including attempts aimed at primary prevention by removal of diabetogenic components in cow's milk. The field is moving fast and it is expected that intervention for IDDM prevention will be offered to an increasing number of individuals found at risk of developing the disease.
对胰岛素依赖型糖尿病（IDDM）发病机制认识的最新进展，已促成了针对易感个体的疾病预防首次试验。目前两项主要试验（烟酰胺和胰岛素试验）正在进行，但在世纪之交前不会有初步结果。采用不同方法的试点试验也在进行中，其中大多数基于诱导免疫耐受，这些试验应为开展更大规模的多中心研究提供新的见解，包括尝试通过去除牛奶中的致糖尿病成分进行一级预防。该领域发展迅速，预计将向越来越多被发现有患该病风险的个体提供IDDM预防干预措施。
