Nakao A, Sakagami K, Uda M, Mitsuoka S, Ito H
Department of Surgery, Shobara Red Cross Hospital, Hiroshima, Japan.
J Gastroenterol. 1998 Apr;33(2):276-9. doi: 10.1007/s005350050083.
We report a case of carcinosarcoma in the transverse colon in a 60-year-old woman. She was admitted to our hospital for further examination of occult blood in October, 1995. Colonoscopy disclosed an elevated lesion with ulceration in the transverse colon, and she underwent right hemicolectomy. Histopathological examination revealed the tumor to consist of both carcinomatous and sarcomatous elements, the latter being more predominant. Immunohistochemistry revealed vimentin immunoreactivity in most of the sarcomatous cells, and S-100 and myoglobin in a few carcinomatous cells. Distinct carcinomatous features were noted in one superficial portion of the tumor, and these carcinomatous cells showed immunoreactivity for epithelial membrane antigen. The patient is alive 14 months after surgery without evidence of recurrence. To our knowledge, this is the fourth reported case of carcinosarcoma of the colon. Our review of the literature disclosed poor prognosis in colonic carcinosarcoma.
我们报告一例60岁女性横结肠癌肉瘤病例。1995年10月，她因进一步检查潜血入住我院。结肠镜检查发现横结肠有一隆起性病变伴溃疡形成，遂行右半结肠切除术。组织病理学检查显示肿瘤由癌性和肉瘤性成分组成，后者更为显著。免疫组化显示大多数肉瘤细胞波形蛋白呈免疫反应性，少数癌细胞S-100和肌红蛋白呈免疫反应性。在肿瘤的一个浅表部分发现明显的癌性特征，这些癌细胞上皮膜抗原呈免疫反应性。患者术后14个月存活，无复发迹象。据我们所知，这是第四例报道的结肠肉瘤病例。我们对文献的回顾显示结肠肉瘤预后较差。
