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本文引用的文献

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Morphine enhances complement receptor-mediated phagocytosis of Cryptococcus neoformans by human microglia.吗啡增强人小胶质细胞对新型隐球菌的补体受体介导的吞噬作用。
Clin Immunol Immunopathol. 1998 May;87(2):163-7. doi: 10.1006/clin.1998.4518.
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Pathology of cryptococcal meningoencephalitis: analysis of 27 patients with pathogenetic implications.隐球菌性脑膜脑炎的病理学：对27例患者的分析及发病机制探讨
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Quantitative analysis of phagocytosis and killing of Cryptococcus neoformans by human peripheral blood mononuclear cells by flow cytometry.采用流式细胞术对人外周血单个核细胞吞噬和杀伤新型隐球菌进行定量分析。
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Cryptococcus neoformans survive and replicate in human microglia.新型隐球菌可在人类小胶质细胞中存活并繁殖。
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Activated microglia inhibit multiplication of Toxoplasma gondii via a nitric oxide mechanism.活化的小胶质细胞通过一氧化氮机制抑制弓形虫的增殖。
Clin Immunol Immunopathol. 1993 May;67(2):178-83. doi: 10.1006/clin.1993.1062.
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Effects of cytokines on multiplication of Toxoplasma gondii in microglial cells.细胞因子对小胶质细胞中弓形虫增殖的影响。
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Human microglial cell defense against Toxoplasma gondii. The role of cytokines.人类小胶质细胞对刚地弓形虫的防御。细胞因子的作用。
J Immunol. 1994 Feb 1;152(3):1246-52.
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Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain.人源与鼠源脑源性活化小胶质细胞介导的一氧化氮生成及神经毒性
J Infect Dis. 1994 Aug;170(2):457-60. doi: 10.1093/infdis/170.2.457.
9
CD4+ T cell-dependent acquired state of immunity that protects the brain against Cryptococcus neoformans.依赖CD4 + T细胞的获得性免疫状态，可保护大脑免受新型隐球菌的侵害。
J Immunol. 1994 Mar 1;152(5):2344-50.
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Role of nitric oxide and melanogenesis in the accomplishment of anticryptococcal activity by the BV-2 microglial cell line.一氧化氮和黑色素生成在BV-2小胶质细胞系实现抗隐球菌活性中的作用。
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细胞因子对人小胶质细胞抗隐球菌活性的影响。

Effect of cytokines on anticryptococcal activity of human microglial cells.

作者信息

Lipovsky M M, Juliana A E, Gekker G, Hu S, Hoepelman A I, Peterson P K

机构信息

Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, Minnesota, USA.

出版信息

Clin Diagn Lab Immunol. 1998 May;5(3):410-1. doi: 10.1128/CDLI.5.3.410-411.1998.

DOI:10.1128/CDLI.5.3.410-411.1998
PMID:9606001
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC104534/
Abstract

The effect of selected cytokines on the antifungal activity of human microglia was studied with encapsulated and acapsular strains of Cryptococcus neoformans. None of the cytokines tested increased the fungistatic activity of microglia, suggesting that killing of cryptococci within the central nervous system is dependent on other host defense mechanisms.

摘要

选用新型隐球菌的包膜菌株和无包膜菌株，研究了特定细胞因子对人小胶质细胞抗真菌活性的影响。所测试的细胞因子均未增强小胶质细胞的抑菌活性，这表明中枢神经系统内隐球菌的杀灭依赖于其他宿主防御机制。