Increased prevalence of immunoglobulin A deficiency in patients with the chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome).
作者信息
Smith C A, Driscoll D A, Emanuel B S, McDonald-McGinn D M, Zackai E H, Sullivan K E
机构信息
Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA.
出版信息
Clin Diagn Lab Immunol. 1998 May;5(3):415-7. doi: 10.1128/CDLI.5.3.415-417.1998.
Abstract
We wished to determine the prevalence of immunoglobulin A (IgA) deficiency in patients with the chromosome 22q11.2 deletion syndrome. A total of 32 patients with the chromosome 22q11.2 deletion were examined for IgA deficiency. We report a 13% (n = 4) prevalence of IgA deficiency in patients with this syndrome. The odds ratio of IgA deficiency in this population is 14.20 (P < 0.0001). This confirms the occurrence of significant humoral deficits in this predominantly cellular immunodeficiency.
摘要
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本文引用的文献
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Clin Immunol Immunopathol. 1998 Feb;86(2):141-6. doi: 10.1006/clin.1997.4463.
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