Clark J A, Callicoat P A, Brenner N A, Bradley C A, Smith D M
Am J Clin Pathol. 1983 Aug;80(2):210-3. doi: 10.1093/ajcp/80.2.210.
The frequency of selective IgA deficiency was determined in a healthy population of 6,240 blood donors. Screening for IgA deficiency was performed by double-diffusion analysis in agarose gel. Confirmation testing was performed with the more sensitive passive hemagglutination inhibition assay. Prevalence of IgA deficiency, characterized by a serum level of below 50 mg/L, was 0.30% (1 in 328), which is the highest prevalence of selective IgA deficiency reported in a healthy population. Antibodies to IgA were detected in sera of 36.8% of the blood donors with selective IgA deficiency, which also is the highest prevalence of anti-IgA antibodies reported in any previous study. The literature on IgA deficiency in healthy populations is reviewed. Current concepts in treatment of IgA-deficient patients requiring blood products are described.
在6240名健康献血者群体中测定了选择性IgA缺乏症的发生率。通过琼脂糖凝胶双向扩散分析进行IgA缺乏症筛查。采用更灵敏的被动血凝抑制试验进行确诊检测。以血清水平低于50mg/L为特征的IgA缺乏症患病率为0.30%（1/328），这是在健康人群中报道的选择性IgA缺乏症的最高患病率。在36.8%的选择性IgA缺乏症献血者血清中检测到了抗IgA抗体，这也是以往任何研究中报道的抗IgA抗体的最高患病率。对健康人群中IgA缺乏症的文献进行了综述。描述了需要血液制品的IgA缺乏症患者治疗的当前概念。
