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用于化学毒理学测试的小鼠喂食器的改进。

Improvement of a mouse feeder for chemical toxicology testing.

作者信息

Matsuzawa T, Kitamura K, Iwasaki M

机构信息

Safety Research Laboratories, Yamanouchi Pharmaceutical Company Ltd., Tokyo, Japan.

出版信息

Exp Anim. 1998 Apr;47(2):123-6. doi: 10.1538/expanim.47.123.

DOI:10.1538/expanim.47.123
PMID:9606423
Abstract

A mouse feeder in common use in the US was modified to eliminate spillage, contamination by excreta and formation of food aggregates. The improved feeder consists of a glass jar which holds 100 g of meal-type feed, an inner metal mesh tube, a marble placed inside the inner mesh tube, and a snap-on metal lid. Female mice [B6C3F1 and CD-1(ICR)] were housed 5 animals/cage. Only slight contamination by feces, but not by urine, was observed in a 13-week feeding study with Japanese meal-type food and the improved feeder. Food spillage also decreased. Food consumption was significantly higher in cages with the conventional Japanese feeder than in the improved one, but no difference was observed between the two feeders in body weight gain.

摘要

对美国常用的一种小鼠喂食器进行了改进,以消除饲料洒落、粪便污染和食物结块现象。改进后的喂食器由一个可容纳100克粉状饲料的玻璃罐、一个内部金属网管、置于内部网管内的一颗弹珠以及一个卡扣式金属盖组成。将雌性小鼠[B6C3F1和CD-1(ICR)]以每笼5只的密度饲养。在一项为期13周的用日本粉状食物和改进后的喂食器进行的喂食研究中,仅观察到轻微的粪便污染,未观察到尿液污染。饲料洒落情况也有所减少。使用传统日本喂食器的笼子里的食物消耗量显著高于使用改进后喂食器的笼子,但两种喂食器在体重增加方面未观察到差异。

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