Nuytten D, Wyffels E, Michiels K, Ferrante M, Verbraeken H, Daelemans R, Baeck E, Cras P
Department of Internal Medicine and Neurology, Stuivenberg General Hospital, Antwerp, Belgium.
Acta Neurol Belg. 1998 Mar;98(1):32-5.
A nineteen year-old girl developed rhabdomyolysis and central pyrexia after the ingestion of multiple drugs: amphetamines, benzodiazepines, methadone, ethanol, and cocaine. On admission, the patient was deeply comatose and during the hospitalisation asymmetrical spastic quadriparesis was noted. Brain biopsy was diagnostic of spongiform leucoencephalopathy. A review of the literature concerning drug-induced spongiform encephalopathy revealed a large amount of heroin-induced cases. The role of cocaine, however, is less well described. After prolonged hospitalisation, our patient improved clinically and radiologically and could be transferred to a rehabilitation center.
一名19岁女孩在摄入多种药物（苯丙胺、苯二氮䓬、美沙酮、乙醇和可卡因）后出现横纹肌溶解和中枢性发热。入院时，患者深度昏迷，住院期间出现不对称性痉挛性四肢瘫。脑活检诊断为海绵状白质脑病。对有关药物性海绵状脑病的文献综述显示，有大量海洛因所致病例。然而，可卡因的作用描述较少。经过长时间住院，我们的患者在临床和影像学上均有改善，并可转至康复中心。
