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[通过琼脂扩散法测定抗生素浓度的新型数学方法。相对生物活性估计的图形、表格和数学选项分析]

[Novel mathematical approach to determination of antibiotics concentration by agar diffusion method. Analysis of graphical, table and mathematical options of relative biological activity estimation].

作者信息

Esipov S E

机构信息

National Research Centre of Antibiotics, Moscow.

出版信息

Antibiot Khimioter. 1998;43(3):8-13.

PMID:9606490
Abstract

Several varieties of relative biological activity estimation are comparatively analyzed and illustrated by an example of tylosin. For visual demonstration the estimates with the equation of a straight line are represented graphically. It is concluded that the design equations in the State Pharmacopeia XI (USSR) should be respectively replaced. The advantages of the variety for the biological activity estimation with the one-point intercept form of the equation of a straight line are illustrated by particular examples.

摘要

对几种相对生物活性估计方法进行了比较分析，并以泰乐菌素为例进行了说明。为了直观展示，用直线方程进行的估计以图形方式呈现。得出结论，苏联第十一部国家药典中的设计方程应分别予以替换。通过具体例子说明了用直线方程的单点截距形式进行生物活性估计方法的优点。

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