[嘧啶衍生物对大鼠皮肤修复再生中抗生素治疗效果的改善作用]
[Improvement of effectiveness of antibiotic therapy by pyrimidine derivatives in reparative regeneration of skin in rats].
作者信息
Ismagilova A F, Zarudiĭ F S, Lazareva D N, Davydova V A, Karachurina L T, Ismagilova Z F, Tropynina Iu G
机构信息
Institute of Organic Chemistry, Ufa Scientific Centre, Russian Academy of Sciences.
出版信息
Antibiot Khimioter. 1998;43(3):19-21.
It was shown on noninbred albino rats with various affections of the skin that pyrimidine derivatives stimulated the skin reparative regeneration and increased the efficacy of antibiotic therapy of Staphylococcus and Proteus infected wounds. The therapeutic effect of 2-methyl-4-amino-6-oxypyrimidine was much higher than that of oxymethyluracil or methyluracil. The pyrimidine derivatives proved to be universal accelerators for reparative regeneration, were compatible with antibiotics and increased their efficacy.
在患有各种皮肤疾病的非近交系白化大鼠身上的实验表明，嘧啶衍生物能刺激皮肤的修复性再生，并提高对感染葡萄球菌和变形杆菌伤口的抗生素治疗效果。2-甲基-4-氨基-6-氧代嘧啶的治疗效果远高于羟甲基尿嘧啶或甲基尿嘧啶。事实证明，嘧啶衍生物是修复性再生的通用促进剂，与抗生素相容并能提高其疗效。
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