KE和CBA近交系小鼠胚胎中原始生殖细胞群体的比较。

The comparison of primordial germ cell populations in embryos of KE and CBA inbred strains of mice.

作者信息

Wabik-Sliz B, Paczuska I, Wiśniewska A, Lenartowicz M

机构信息

Department of Genetics and Evolution, Jagiellonian University, Kraków, Poland.

出版信息

Folia Histochem Cytobiol. 1998;36(2):81-5.

PMID:9606622

Abstract

The changes in primordial germ cell (PGC) populations were compared in embryos of two inbred strains of mice-KE and CBA/Kw on 11, 12, 13 and 14 day of foetal life. The number of PGCs did not differ in 11-day embryos of both strains. In 12-day CBA/Kw embryos the proliferation rate of PGCs was higher and the number of PGC was significantly higher than in 12-day KE embryos. However, on subsequent days the PGC proliferation rate decreased in CBA/Kw but rapidly increased in KE embryos, leading to significantly higher number of PGCs in 14-day KE embryos. These differences in proliferation rate between KE and CBA/Kw PGCs can be regarded as the reason of strong selection against CBA/Kw derived gametes observed in KE<-->CBA aggregation chimaeras.

摘要

在胎儿期第11、12、13和14天，对两种近交系小鼠（KE和CBA/Kw）胚胎中的原始生殖细胞（PGC）群体变化进行了比较。两种品系11天胚胎中的PGC数量没有差异。在12天的CBA/Kw胚胎中，PGC的增殖率较高，且PGC数量显著高于12天的KE胚胎。然而，在随后的几天里，CBA/Kw胚胎中PGC的增殖率下降，而KE胚胎中PGC的增殖率迅速上升，导致14天的KE胚胎中PGC数量显著增加。KE和CBA/Kw PGCs增殖率的这些差异可被视为在KE<-->CBA聚集嵌合体中观察到的对CBA/Kw来源配子进行强烈选择的原因。