Pancino G, Leste-Lasserre T, Burgard M, Costagliola D, Ivanoff S, Blanche S, Rouzioux C, Sonigo P
Génétique des Virus et Immunopharmacologie Moléculaire, Institut Cochin de Génétique Moléculaire, Laboratoire de Virologie, Paris, France.
J Infect Dis. 1998 Jun;177(6):1737-41. doi: 10.1086/517435.
The presence of antibodies able to enhance infection in vitro in sera from human immunodeficiency virus (HIV)-1-infected patients raises the possibility that antibodies exert a deleterious activity during natural infection. The anti-HIV-1 humoral response and plasma HIV-1 RNA were measured in a cohort of 98 infected mothers, included in the French Prospective Study on Pediatric HIV Infection, 49 of whom transmitted HIV to their children. Transmission from mother to child was associated with antibody responses to the envelope gp160 (P = .009 for serum dilution of 1/400) and to a highly conserved domain of the transmembrane glycoprotein (P = .055 for serum dilution of 1/400) and with plasma HIV-1 RNA levels (P < .0001). Multivariate logistic regression indicated that a high anti-gp160 response and a high plasma virus load are independent risk factors for perinatal transmission of HIV-1 (odds ratio, 3.4; 95% confidence interval, 1.1-9.9 for anti-gp160; odds ratio, 2.8; 95% confidence interval, 1.6-5.0 for virus load).
在人类免疫缺陷病毒1型（HIV-1）感染患者的血清中存在能够在体外增强感染的抗体，这增加了抗体在自然感染过程中发挥有害作用的可能性。在一项针对98名感染母亲的队列研究中，检测了她们的抗HIV-1体液反应和血浆HIV-1 RNA水平，该队列研究纳入了法国儿科HIV感染前瞻性研究，其中49名母亲将HIV传播给了她们的孩子。母婴传播与针对包膜糖蛋白gp160（血清稀释度为1/400时P = 0.009）和跨膜糖蛋白高度保守结构域（血清稀释度为1/400时P = 0.055）的抗体反应以及血浆HIV-1 RNA水平（P < 0.0001）相关。多因素逻辑回归表明，高抗gp160反应和高血浆病毒载量是HIV-1围产期传播的独立危险因素（抗gp160的比值比为3.4；95%置信区间为1.1 - 9.9；病毒载量的比值比为2.8；95%置信区间为1.6 - 5.0）。
