Dyer J R, Kazembe P, Vernazza P L, Gilliam B L, Maida M, Zimba D, Hoffman I F, Royce R A, Schock J L, Fiscus S A, Cohen M S, Eron J J
Department of Medicine, University of North Carolina, Chapel Hill 27599-7030, USA.
J Infect Dis. 1998 Jun;177(6):1742-6. doi: 10.1086/517436.
High levels of human immunodeficiency virus type 1 (HIV-1) replication, as reflected in HIV-1 RNA concentrations in blood and semen, probably contribute to both rapid disease progression and enhanced sexual transmission. Semen and blood were collected from 49 Malawian and 61 US and Swiss (US/Swiss) HIV-1-seropositive men with similar CD4 cell counts and no urethritis or exposure to antiretroviral drugs. Median seminal plasma and blood plasma HIV-1 RNA concentrations were >3-fold (P = .034) and 5-fold (P = .0003) higher, respectively, in the Malawian men. Similar differences were observed in subsets of the Malawian and US/Swiss study groups matched individually for CD4 cell count (P = .035 and P < .002, respectively). These observations may help explain the high rates of HIV-1 sexual transmission and accelerated HIV-1 disease progression in sub-Saharan Africa.
血液和精液中人类免疫缺陷病毒1型（HIV-1）RNA浓度所反映的高水平HIV-1复制，可能导致疾病快速进展和性传播增强。从49名马拉维和61名美国及瑞士（美/瑞）HIV-1血清反应阳性男性中采集精液和血液，这些男性的CD4细胞计数相似，且无尿道炎或未接触抗逆转录病毒药物。马拉维男性精液血浆和血液血浆中HIV-1 RNA浓度中位数分别高出3倍多（P = .034）和5倍（P = .0003）。在根据CD4细胞计数单独匹配的马拉维和美/瑞研究组亚组中也观察到类似差异（分别为P = .035和P < .002）。这些观察结果可能有助于解释撒哈拉以南非洲地区HIV-1性传播率高和HIV-1疾病进展加速的现象。
