Bazhan S I, Belova O E
Vestn Ross Akad Med Nauk. 1998(3):18-24.
Interferons (IFN) are cytokines with a wide range of biological activities. The most important function of IFN is associated with the induction of host resistance to viral infections. This paper discusses the well-known experimental data and the results of the authors' theoretical studies of the regularities of type 1 interferon induction and its antiviral action. The mechanisms both of interferon gene expression and transcription regulation of IFN-stimulated genes by IFNs and viruses are analyzed. The molecular mechanisms of IFN-induced resistance and the well-known strategies acquired by viruses to overcome IFN action are discussed. The authors' analyze possible regulation by IFN of its own expression and the role of IFN- and virus-induced expression of genes of antiviral response in the development of resistance to infection.
干扰素（IFN）是一类具有广泛生物学活性的细胞因子。IFN最重要的功能与诱导宿主抵抗病毒感染有关。本文讨论了关于1型干扰素诱导规律及其抗病毒作用的著名实验数据和作者的理论研究结果。分析了干扰素基因表达以及IFN和病毒对IFN刺激基因转录调控的机制。讨论了IFN诱导抗性的分子机制以及病毒为克服IFN作用而采用的著名策略。作者分析了IFN对其自身表达可能的调控以及IFN和病毒诱导的抗病毒反应基因表达在抗感染抗性发展中的作用。
