Parsa M A, Bastani B
Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA.
J Neuropsychiatry Clin Neurosci. 1998 Spring;10(2):216-9. doi: 10.1176/jnp.10.2.216.
Psychoses are a common clinical problem in patients with Parkinson's disease. Treatment with typical neuroleptics or withdrawal of antiparkinsonian drugs may improve mental symptoms but will worsen the parkinsonism. Quetiapine (Seroquel), ICI 204,636, is a novel antipsychotic medication with a low potential for producing extrapyramidal side effects. In this open-label clinical study of 2 patients with Parkinson's disease, treatment with Seroquel successfully controlled psychotic symptoms without worsening of motor disability.
精神病是帕金森病患者常见的临床问题。使用典型抗精神病药物治疗或停用抗帕金森病药物可能会改善精神症状，但会加重帕金森病症状。喹硫平（思瑞康），ICI 204,636，是一种新型抗精神病药物，产生锥体外系副作用的可能性较低。在这项针对2例帕金森病患者的开放标签临床研究中，使用思瑞康治疗成功控制了精神症状，且未加重运动功能障碍。
