Tsai G E, Falk W E, Gunther J
Geriatric Neurobehavioral Clinic, Massachusetts General Hospital, Charlestown, USA.
J Neuropsychiatry Clin Neurosci. 1998 Spring;10(2):224-6. doi: 10.1176/jnp.10.2.224.
D-cycloserine is a partial agonist on the glycine site of the N-methyl-D-aspartate glutamate receptor. This double-blind crossover study of 15 mg D-cycloserine in Alzheimer's disease patients did not demonstrate clinical benefit. Higher medication dosage or long-term treatment may be required.
D-环丝氨酸是N-甲基-D-天冬氨酸谷氨酸受体甘氨酸位点上的部分激动剂。这项针对阿尔茨海默病患者使用15毫克D-环丝氨酸的双盲交叉研究未显示出临床益处。可能需要更高的药物剂量或长期治疗。
