Burke W J, Pfeiffer R F, McComb R D
Department of Psychiatry, University of Nebraska Medical Center, Omaha, USA.
J Neuropsychiatry Clin Neurosci. 1998 Spring;10(2):227-9. doi: 10.1176/jnp.10.2.227.
Dementia with Lewy bodies (DLB) may be one of the most common causes of dementia. It should be of particular interest to psychiatrists because hallucinations are common presenting symptoms and because patients with DLB may be particularly sensitive to neuroleptics with respect to developing extrapyramidal symptoms. The authors describe 2 patients with DLB who were intolerant of clozapine, showing not extrapyramidal side effects, but an increase in confusion and behavioral symptoms.
路易体痴呆（DLB）可能是最常见的痴呆病因之一。精神科医生应特别关注它，因为幻觉是常见的症状，而且DLB患者在出现锥体外系症状方面可能对神经阻滞剂特别敏感。作者描述了2例对氯氮平不耐受的DLB患者，这些患者未出现锥体外系副作用，而是出现了意识模糊和行为症状加重的情况。
