Kratzsch K H, Zimmermann S, Morenz J, Fürstenau M, Zugehör M, Claus B, Lewicki I
Z Gesamte Inn Med. 1976 Jul 15;31(14):533-5.
In 60 patients with a morphologically ascertained chronic liver disease and 40 hepatologically examined patients with a healthy liver of a control group the quantitative determination of the immunoglobulin and the immunofluorescence-serological determination of antibodies against nuclei, smooth musculature and mitochondria were carried out. Only in one female patient with a chronic active hepatitis out of 51 patients with morphologically ascertained liver cirrhosis or chronic active hepatitis antibodies against nuclei and smooth musculature in a level of the titre of more than 1 : 40 and only in 2 female patients with a primary biliary cirrhosis antibodies against mitochondria could be proved in a level of the titre of more than 160. Titres of antibodies lying below were found in the group of patients with liver diseases and the control group in the same frequency, so that an autoimmune form of the cryptogenic cirrhosis could not be differentiated. The proof of antibodies against nuclei and smooth musculature of a high titre in connection with an isolated increase of the IgG is of special diagnostic importance for the autoimmune form of the chronic active hepatitis; the same is the case in the proof of antibodies against mitochondria of a high titre in connection with an isolated increase of IgM.
对60例经形态学确诊的慢性肝病患者以及40例作为对照组的经肝脏学检查的肝脏健康患者进行了免疫球蛋白的定量测定以及针对细胞核、平滑肌和线粒体抗体的免疫荧光血清学测定。在51例经形态学确诊的肝硬化或慢性活动性肝炎患者中，仅1例患有慢性活动性肝炎的女性患者抗细胞核和平滑肌抗体滴度超过1:40，仅2例原发性胆汁性肝硬化女性患者抗线粒体抗体滴度可证实超过160。低于该滴度的抗体在肝病患者组和对照组中出现频率相同，因此无法区分隐源性肝硬化的自身免疫形式。高滴度抗细胞核和平滑肌抗体伴IgG单独升高的证据对于慢性活动性肝炎的自身免疫形式具有特殊诊断意义；高滴度抗线粒体抗体伴IgM单独升高的证据情况相同。
