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[肉碱在人体脂质代谢中的作用]

[The role of carnitine in human lipid metabolism].

作者信息

Pietrzak I, Opala G

机构信息

Studium Doktoranckiego Slaskiej Akademii Medycznej w Katowicach.

出版信息

Wiad Lek. 1998;51(1-2):71-5.

PMID:9608835
Abstract

Carnitine is an important nutrient that is present in diet (particularly in meat and dairy products) and is synthesized from amino acids. Carnitine has two principal functions in the organism. One is to transport long-chain fatty acids into the mitochondrion. The second function of carnitine is to regulate the intramitochondrial ratio of acylocoenzyme A to free coenzyme A. This function is important because it allows to remove excessive (and potentially toxic) short- and medium-chain fatty acids from the mitochondrion, and because it maintains sufficient free coenzyme A within the mitochondrion to support energy metabolism.

摘要

肉碱是一种重要的营养素,存在于饮食中(尤其是肉类和乳制品),并由氨基酸合成。肉碱在生物体内有两个主要功能。一是将长链脂肪酸转运到线粒体中。肉碱的第二个功能是调节线粒体内酰基辅酶A与游离辅酶A的比例。这个功能很重要,因为它能从线粒体中清除过量的(且可能有毒的)短链和中链脂肪酸,还因为它能在线粒体内维持足够的游离辅酶A以支持能量代谢。

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