Ermentrout G B, Edelstein-Keshet L
Department of Mathematics, University of Pittsburgh, PA 15260, USA.
Bull Math Biol. 1998 May;60(3):477-503. doi: 10.1006/bulm.1997.0012.
In a previous paper, we studied elementary models for polymerization, depolymerization, and fragmentation of actin filaments (Edelstein-Keshet and Ermentrout, 1988, Bull. Math. Biol. 60, 449-475). When these processes act together, more complicated dynamics occur. We concentrate on a particular case study, using the actin-fragmenting protein gelsolin. A set of biological parameter values (drawn from the experimental literature) is used in computer simulations of the kinetics of gelsolin-mediated actin filament fragmentation.
在之前的一篇论文中，我们研究了肌动蛋白丝聚合、解聚和断裂的基本模型（埃德尔斯坦 - 凯谢特和厄门特劳特，1988年，《数学生物学公报》60卷，449 - 475页）。当这些过程共同作用时，会出现更复杂的动力学。我们专注于一个特定的案例研究，使用肌动蛋白切割蛋白凝溶胶蛋白。一组生物学参数值（取自实验文献）被用于计算机模拟凝溶胶蛋白介导的肌动蛋白丝断裂动力学。
