Mastick C C, Brady M J, Printen J A, Ribon V, Saltiel A R
Department of Cell Biology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA.
Mol Cell Biochem. 1998 May;182(1-2):65-71.
Insulin is a potent stimulator of intermediary metabolism, however the basis for the remarkable specificity of insulin's stimulation of these pathways remains largely unknown. This review focuses on the role compartmentalization plays in insulin action, both in signal initiation and in signal reception. Two examples are discussed: (1) a novel signalling pathway leading to the phosphorylation of the caveolar coat protein caveolin, and (2) a recently identified scaffolding protein, PTG, involved directly in the regulation of enzymes controlling glycogen metabolism.
胰岛素是中间代谢的强效刺激物，然而胰岛素对这些代谢途径的刺激具有显著特异性，其基础在很大程度上仍不为人知。本综述聚焦于区室化在胰岛素作用中的角色，包括信号起始和信号接收过程。文中讨论了两个例子：（1）一条导致小窝衣被蛋白小窝蛋白磷酸化的新信号通路，以及（2）一种最近鉴定出的支架蛋白PTG，它直接参与调控控制糖原代谢的酶。
