Resh M D
Cell Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Cell Signal. 1996 Sep;8(6):403-12. doi: 10.1016/s0898-6568(96)00088-5.
Covalent modification by fatty acylation and prenylation occurs on a wide variety of cellular signalling proteins. The enzymes that catalyze attachment of these lipophilic moieties to proteins have recently been identified and characterized. Each lipophilic group confers unique properties to the modified protein, resulting in alterations in protein/protein interactions, membrane binding and targeting, and intracellular signalling. The biochemistry and cell biology of protein myristoylation, farnesylation and geranylgeranylation is reviewed here, with emphasis on the Src family of tyrosine kinases, Ras proteins and G protein coupled signalling systems.
通过脂肪酰化和异戊二烯化进行的共价修饰发生在多种细胞信号蛋白上。最近已经鉴定并表征了催化这些亲脂性部分与蛋白质连接的酶。每个亲脂性基团赋予修饰后的蛋白质独特的性质，导致蛋白质/蛋白质相互作用、膜结合与靶向以及细胞内信号传导发生改变。本文综述了蛋白质肉豆蔻酰化、法尼基化和香叶基香叶基化的生物化学和细胞生物学，重点关注酪氨酸激酶的Src家族、Ras蛋白和G蛋白偶联信号系统。
