Ashworth J R, Warren A Y, Johnson I R, Baker P N
Department of Obstetrics and Gynaecology, University of Nottingham, Nottingham City Hospital, UK.
Br J Obstet Gynaecol. 1998 Apr;105(4):459-61. doi: 10.1111/j.1471-0528.1998.tb10134.x.
This study assesses the ability of plasma from women with pre-eclampsia to induce altered endothelial function in myometrial resistance vessels from normotensive women. Vessels from normotensive pregnant women (n = 7) were incubated with plasma from other pregnant women who were normotensive (n = 6) or had pre-eclampsia (n = 7). A wire myograph was used to test the endothelium-dependent relaxatory response to bradykinin of preconstricted vessels. The relaxation in vessels incubated with plasma from women with pre-eclampsia was markedly less than in vessels incubated with plasma from normotensive pregnant women (P = 0.039). This supports the theory that a plasma-borne factor contributes to the endothelial changes seen in pre-eclampsia.
本研究评估了子痫前期女性血浆诱导血压正常女性子宫肌层阻力血管内皮功能改变的能力。将血压正常的孕妇（n = 7）的血管与其他血压正常（n = 6）或患有子痫前期（n = 7）的孕妇的血浆一起孵育。使用线式肌张力测定仪测试预收缩血管对缓激肽的内皮依赖性舒张反应。与子痫前期女性血浆孵育的血管中的舒张明显小于与血压正常孕妇血浆孵育的血管（P = 0.039）。这支持了一种理论，即一种血浆携带因子促成了子痫前期所见的内皮变化。
