Mitsui N, Fukunaga S, Sueda T, Matsuura Y, Havlik P, Trinkl J, Demunck J L, Mesana T, Montiès J R
First Department of Surgery, Hiroshima University School of Medicine, Japan.
Artif Organs. 1998 May;22(5):419-25. doi: 10.1046/j.1525-1594.1998.06129.x.
The influence of the Wankel type semipulsatile left ventricular assistance on hemodynamics was investigated with a computer simulation and an animal experiment. A simulation circuit was constructed to express the circulatory system. A current source was added to create a semipulsatile blood pump. The left and right ventricles were replaced by variable compliances. Left heart failure was simulated by decreasing the amount of compliance change of the left ventricle. Under the condition of heart failure when semipulsatile assist flow increased, the mean aortic pressure (AoP), tension time index (TTI), and diastolic pressure time index (DPTI) increased, and the cardiac output, pulse pressure (PP), and pulsatility indicator (PI) decreased. In an animal experiment, a Wankel type blood pump was used in a calf. With the increase of the assist flow, AoP curves became less pulsatile, and PP and PI decreased in accordance, which was predicted by the numerical simulation.
通过计算机模拟和动物实验研究了汪克尔型半搏动式左心室辅助对血流动力学的影响。构建了一个模拟电路来表示循环系统。添加了一个电流源以创建一个半搏动式血泵。左右心室被可变顺应性所取代。通过减少左心室顺应性变化量来模拟左心衰竭。在心力衰竭情况下，当半搏动辅助血流增加时，平均主动脉压（AoP）、张力时间指数（TTI）和舒张压时间指数（DPTI）增加，而心输出量、脉压（PP）和搏动指标（PI）降低。在动物实验中，在一头小牛身上使用了汪克尔型血泵。随着辅助血流的增加，AoP曲线的搏动性降低，PP和PI相应降低，这与数值模拟预测的结果一致。
